My PRS-650 locked up once due to a badly formated EPUB.
I did the standard reset, but it didn't seem to work at first until I found that I had to both press the internal paper-clip reset for about 5 seconds and then follow up by HOLDING the power slider switch ON for several seconds to get the reader to start booting (it would ignoor a quick toggle on the power slider switch).
You might try this if you have not already.
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