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Granted that one might base a character more or less loosely on someone one actually knows, but if the OP implies killing off a character called James Wilde, based on someone he knows called James Wilde, I have to say I think that would be in bad taste.
And it could get you in serious trouble if the character is someone significant in the real world, for example a story about the assassination of a president and using an actual president as the character. The CIA and MI5/6 and similar organisations have absolutely no sense of humour.
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