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In fact, the Nook is my first device for the EPUB files I build and when 'epubcheck' works and the Nook renders ok, chances are fairly good the books are ok elsewhere too...
As for the font, I never specify these properties because the reader ought to be free to define how he/she'd like to have the book rendered. I might set the justification, but font size is set through "small" or "larger" rather than pixel sizes.
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