Atlantis Word Processor or Jutoh allow you to work in a word processor atmosphere prior to publishing the file as an epub.
These programs both have limitations, so if you are looking for a easy program that will create exceedingly complex layouts or include tables, you are pretty much out of luck.
But you are likely to be out of luck in an entirely different way. These sorts of layouts are not done well or predictably with the epub format. This is because epubs can have their text resized at will by the reader and the text reflows as the size changes.
For fixed layout, pdf is best, but is not a format which sold by the big distributors.
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