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a 6" screen is almost exactly the same size as a volume of manga it's really the size you should be aiming at for comfortable reading.
The biggest issue for reading manga is resolution. 800x600 means you lose detail. This isn't an issue for the artwork but it can make small text harder to read. Thankfully Calibre and other converters have functions that really help for this, sharpening filters and increasing the contrast works wonders.
I've read the entirity of One Piece on a PRS-505 with no issue whatsoever (except for the inconsistent file structures in zips making conversion a pain sometimes)
Given 95% of manga is purely black and white, lack of colour isn't an issue. You do want 8 levels of grey as an absolute minimum though.
As for LCD vs E-ink. Low Battery life and eye strain are an issue, plus the fact that you're probably going to be dealing with a lowish quality screen are things to factor in.
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