I've had this happen with a few books. In my case it had to do with the size of the html files inside the epub. Most html files are well under 100K. I forget at what point it starts to slow the reader down, but whenever I see anything above 150K, I try to split the file if I can (and when I did this with the sluggish books, they returned to normal). If there's a file over 300K, my PRS-350 won't even open the book and gives me a "Page Error!" message.
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