If I read in the dark, I prefer my LCD (transflective or transmissive) screen, with the backlight turned all the way down, with a black background and gray lettering.
When I read on my transflective screen in a well-lit environment (I won't use my transmissive screen there), I turn off the backlight, and change to a ivory background with black letters. The e-ink screen, with the somewhat grayish background, fits perfectly with my desired colour scheme (I don't like white backgrounds, I don't even like pure white paper in books...)
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