Ahi makes really valid points, and makes them well.
We are barely entering the infancy of e-publishing. Just like at the dawn of personal computing, there are a myriad of custom screen sizes, and the experience is largely text-based.
But I think, many here are ignoring the fact, that as e-publishing matures, much more complex layouts will become available.
Also, screen sizes will become larger, and will become more standardized, as color, high-res hardware becomes available. Magazines, visually-complex titles, and ads, will demand much more robust format capabilities.
Just like many websites today are designed with minimum resolution requirements, and are of fixed layout, so it will be with many publications.
The plain, often ugly, reflowable text, on 2" screens, will one day seem like primitive notches on a stick....
