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I had a 334 MB PDF, which was a book straight color scanned. My Sony PRS500 did digest it, but it was difficult to read (speed was not an issue) because of contrast and size. I reformatted it with rasterfarian and now have a perfectly readable 24 MB file. So 100 MB is not an issue, however if it is a straight scan you may be able to improve size and readability.
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