Well, for classes for which I had to read novels, I did use my reader. It was less convenient because it took longer to get to parts that I had bookmarked (press button...wait.... press another button...wait...instead of just opening the book to where I'd stuck a post-it note) but since I had to read four or five novels simultaneously, I found the reduced bulk in my bag worth it.
I had an econ class where the textbook was an ebook, but I accessed it on my computer instead, because a giant econ book filled with graphs and pictures isn't going to display nicely on my little 6" screen. I liked it a lot better than a paper textbook - cheaper, less bulky, and I can search for terms I want instantly instead of having to look things up in the index.
Funny enough, my courses now don't have textbooks at all. All of our material is taught from articles in scholarly journals, which have been scanned and posted online. It means no books to buy and I just have to bring my laptop. I would be in favor of moving away from a paper-book-based education model.
