On my Nook HD/HD+ with their LED screens, I prefer to use Cool Reader because in addition to adjusting the brightness, I can change the background screen color from stark white to a very pale green-gray color, which I find doesn't annoy my eyes like reading for hours on a laptop will do.
The Nook and Kindle apps just seem to give the options of various permutations of black, white, gray and sepia backgrounds.
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