Well, the Sony PRS-350 and PRS-650 are probably the most easily accessible readers that are not connected to a book store by at least wifi. The Kobo and Nook both are tied to their respective stores.
There are a number of the smaller players who lack wifi on at least some of their models. That being said, with the exception of the Jetbook Mini, I can't think of any readers that cannot be registered with Adobe (or in the case of the Kindle with Amazon). And no book reader will prevent a user from side loading DRM free books.
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Bill
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