For ePUB, I would forget about it, at least until it is supported in the spec. Meanwhile, use other methods for emphasis, like italics, bold, underline... Of course, once it is supported, you can easily change the CSS.
Regarding "workarounds" I'd avoid them, code the style for browsers/readers that work properly (not adding a space after the last letter). At most, you could use ADE's conditional styles for it.
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