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I nominate 'The Immortal Life of Henrietta Lacks' by Rebecca Skloot. It is a really fascinating book about a woman whose cells became the first 'immortal line' in medical research and 50 years after her death, are still being used and have led to many medical discoveries. Her family did not find out this was even going on until years after her death. It's a very interesting story.
I'll also second Omnivore's Dilemma.
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