I know it's an old thread, but I have an issue with large documents that have a lot of cropped hidden information (where I'm extra interested in getting rid of it, so I'd reduce the size); namely, my Acrobat bugs up halfway through and can't complete the process, claiming that the file size is too big. (I don't remember the exact wording now, but I can check it again.) I'm talking about files 100-200 MB in size, so not gigantic, but pretty big. Any idea what I can do there?
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