If you compare a Nook and a PRS-350 you do have to connect the 350 to load books to it. BUT, you need to do that with the Nook as well for books you don't buy from B&N.
If battery time is important to you the Nook will probably have to be charged 4 times (or more) in the time the 350 goes on one charge.
Both are really good readers though. I have both and really like them both! I actually find the Nook more comfortable for "couch reading" but the 350 is pretty hard to beat for portability.
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