For me, personally, it don't believe it'll make a great deal of difference. I find it tiring to read anything long on a PC screen - so a dedicated reader would probably just replace the cellulose. Certainly as HarryT says, I will probably use a dictionary search, to enhance the reading experience.
I am a fairly regular reader and from what I can see there is more than sufficient quantity of novels available to keep me happy for a very long time.
Indeed because of the vast array of 'free-books' available I am likely to find I am reading books that I may not have even considered when looking at p-backs etc.
Only thing I may not be able to do, is read in the bath
, though I notice a few waterproof options on some threads !!