I have a PRS-650 with about 1250 EPUB titles from feedbooks on an SD card.
Opening books, page turns, searches, and all other reading related activities seem to be just as fast.
The only delay I have noticed is a very slight increase in the delay in exiting a book and going back to the HOME page.
Presumably because of the large number of titles that the reader has to populate in the HOME screen index, this time has increase from approximately 2 seconds originally to approximately 4 seconds with 1250 EPUB titles on the SD card.
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