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You can delete the Sony Library software without adverse effects. You won't be able to shop on Sony's site. But Sony's software is not necessary to use and enjoy your reader.
Calibre is an excellent library management program. I use it exclusively to organize my ebook library, change format, and transfer to the reader.
If you do decide to download a DRM'd book from some site, a library for instance, you will need Adobe Digital Editions installed and configured.
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