I personally wouldn't nuke the CSS, depending on how the book was made you'll lose things like italics, bolding, indents, etc. but to each their own. Plenty of folks are happy reading a plain text file with pretty much all formatting missing and depending on how the ePub was made you may or may not lose everything.
Kudos to thekidintheclock for trying to help folks out.
Last edited by AnemicOak; 05-11-2010 at 10:55 PM.