In my desire to get us thinking outside of category/genre and to get us searching for something in uncharted territories, I'm going to use my third nomination for
Planes, Trains and Automobiles
Books must feature planes or trains or automobiles prominently as characters, or plot determiners. So something like Murder on the Orient Express works since the setting on the train figures prominently into the plot. Christine would be another good choice since the car is the main antagonist in the plot. Crash by J.G. Ballard would work since the vehicle is a large portion of the story. Or maybe Flight into Danger by Hailey where the setting on the plane is a key part of the action.