Thanks for your reply. I ended up getting everything working. I made an actual environment variable on my system instead of just using the calibre-portable.bat. Doing this worked right away.
It is taking several minutes to load my library though. It seems faster than before, but still takes a while. Not complaining, but I am wondering if this is fairly normal. Anything I can do to speed it up? I have disabled several columns in the main display window which helped loading times.