I went from a 505 to a 650 awhile ago. The 505's screen/technology would be similar to the 300 (only a bigger screen). And at the beginning of this year, I added a 350 to my reader collection when Sony was selling their refurbished units for a cheap price. I have to say that although I loved my 505, the 650 and 350 are both the best readers I have ever used, and I hope nothing ever happens to them! When I compared the clarity of the 650 and 350 to the 505, they were much clearer (and I was always happy with my 505 screen). But the added bonus of having built in dictionary and the touch screen interface makes the 650/350 much more useful to me. And I agree with Ripplinger and Grumbles--I have no problems at all with fingerprints. And as Helen (speakingtohe) pointed out, the 350/650s have page turn buttons and a stylus, so there really is no need to directly touch the screen at all if you don't want to.