Originally Posted by exaltedwombat
And if you DO decide to design in InDesign and attempt to use its direct-to-epub or direct-to-mobi function, make sure you have only used a very simple subset of InDesign's layout options. Otherwise you'll get VERY messy, bloated code (or a crash).
Elizabeth Castro's book EPUB Straight to the Point
has lots of good information about making epubs from Indesign documents.
But IMHO one still needs to use Sigil to tweak the Indesign-exported epub.