I suspect you'll get it started again. Are you plugging it into a wall outlet? That would be preferable. Once you get it restarted, do the Factory Reset again, and just add one book. Let it get through its indexing processes, then read that one book. If the Kindle behaves itself, you've got a corrupt file that you've been loading. If it acts up again, you've got a different problem.
I can help you with Mac specific questions. It's just a matter of getting the Kindle to respond again first.