Originally Posted by hwlester
I'm not sure what publishers are using to typeset current books, but Adobe InDesign has EPUB support built right into the product, so lay out the print book, then export it straight to EPUB. Getting it from EPUB to MOBI for Amazon and retaining the formatting might not be as trivial, but the EPUB should be as good as the print version on modern books, anyway.
Perhaps you're not aware that InDesign's ePub export is hardly the turn-key affair it's advertised as? Many people have found they have nearly as much work involved fixing/tweaking an ePub that InDesign has created as they would have had they simply started from scratch.