Five Guys, definitely. I just wish there was one closer than four hours away. Culver's is my favorite local burger. Only had In-N-Out once, but it was good enough rank up there. I'm not impressed with Fuddruckers or A&W, and I've never heard of Smashburger.
I'm gonna catch flack for this, but I like Jack-in-the-Box for a quick burger and White Castle every once in a while.