Yeah but if the file size is 110 MB... A lot of people won't be too happy - for instance the Nook Touch users. Even though it's advertised as having 2 GB storage, the actual space (for non-B&N store bought books) is around 200 MB.
Hmm... 1500 images? That's not a book, that's a photo album! If many of them are similar you could choose one and simply display it in several parts of the book.