One of the first things I did when I received my Opus was to disable the accelerometer. I have something similar on my phone and it annoys the heck out of me.
I'm right handed so the page turn buttons are in the right place, but when I read in bed at night, I lie on my right side holding the Opus with my left hand, and the main navigation button makes a good substitute for the page turns.
Can you tell that I'm in love my Opus? LOL! The only thing missing, IMO, is a clock.