Hmmm, I had a phone that did this. It was a Palm Treo and whenever I tried to sync it with my computer, the USB connection would keep dropping. I tried a new cable and still had problems. My phone was over a year old when I started having this problem so I couldn't get it replaced. I had to hold the cable JUST SO the entire time I synced it, or the connection would drop (and it often did anyway). I think there was a problem with the pins inside the port on the phone. If the Reader is new, I would get it replaced.