I've actually gone so far as looking into removing the right-side button. I tried to pry it up, and from what I can see, it connects similar to how a space bar connects. But I wasn't able to get it off. I'll wait until my return option runs out (if there is a return option!).
I am left handed, which means I want to navigate with my left hand and hold the device with my right hand. I've tried to hold it like rflashman says, you sort of learn to do that. And when I use the cover, it works ok, but the cover is a whole different story.
If anything has my panties knotted up, it's simply that right side button. It's just too much.